• FiteBac® K18 QAMS covalently attaches a well known biocide, Quaternary Ammonium compound with C18 ligand, to a silane core containing acrylate functionality
    • Acrylate functionality allows for co-polymerization within several polymer systems
  • Antimicrobial does not migrate from the polymer
    • Normal wear of a dental device exposes fresh K18 QAMS offering continuous microbiological protection
  • K18 QAMS has been FDA cleared as a component in certain dental appliance resins
  • Patent protection until 2033

Video Explanation: Example of plaque biofilms containing mixed bacterial-fungal components.

(a) BacLightstained CLSM merged image showing the presence of live (green) fungal hyphae (open arrowhead) within the biovolume of a biofilm taken from a control disk of one subject (subject 21).

(b) The corresponding BacLightstained CLSM merged image showing the presence of dead (red) fungal hyphae killed by the QAMS-containing acrylic (open arrowhead) from an experimental disk of the same subject.

K18 QAMS in an FDA 510(k) Approved Antimicrobial MMA/PMMA Acrylic Resin System

The addition of K18 QAMS to a MMA/PMMA acrylic resin has been shown to improve fracture toughness without adversely affecting flexural modulus and strength of the orthodontic acrylic.

In vitro studies, performed by Dr. Frank Tay, Dental College of Georgia at Augusta University, of orthodontic acrylic resins containing 4–6% K18 QAMS have been shown to possess both in vitro immediate diffusional as well as contact-killing antimicrobial properties when tested with Streptococcus mutans, Actinomyces naeslundii and Candida albicans.