- FiteBac® K18 QAMS is a well known Si-Quat biocide covalently bound to a silane core containing acrylate functionality
- Acrylate functionality allows for co-polymerization within several polymer systems
- Antimicrobial does not migrate from the polymer
- Normal wear of a dental device exposes fresh K18 QAMS creating continuous microbiological protection
- K18 QAMS has been FDA cleared as a component in certain dental appliance resins
- Patent protection until 2033
Video Explanation: Example of plaque biofilms containing mixed bacterial-fungal components.
(a) BacLightstained CLSM merged image showing the presence of live (green) fungal hyphae (open arrowhead) within the biovolume of a biofilm taken from a control disk of one subject (subject 21).
(b) The corresponding BacLightstained CLSM merged image showing the presence of dead (red) fungal hyphae killed by the QAMS-containing acrylic (open arrowhead) from an experimental disk of the same subject.
(1) Gong, et.al 'An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties', PLoS one, (2012) Vol 7 (8)
K18 QAMS in an FDA 510(k) Cleared Antimicrobial MMA/PMMA Acrylic Resin System
The addition of K18 QAMS to a MMA/PMMA acrylic resin has been shown to improve fracture toughness without adversely affecting flexural modulus and strength of the orthodontic acrylic. (1)
In vitro studies, performed by Dr. Frank Tay, Dental College of Georgia at Augusta University, of orthodontic acrylic resins containing 4–6% K18 QAMS have been shown to possess both in vitro immediate diffusional as well as contact-killing antimicrobial properties when tested with Streptococcus mutans, Actinomyces naeslundii and Candida albicans. (1)