Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities.
The newly developed antibacterial quaternary ammonium silane increases the
resistance of dentin collagen to degradation by inhibiting endogenous matrix metalloproteinases and
cysteine cathepsins. The quaternary ammonium silane cavity disinfectant is promising for use as a
protease inhibitor to improve durability of resin-dentin bonds.